(3E,5E)-1-[(2,5-Dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-4-piperidinone
HO-3867
CAS: 1172133-28-6
Molecular Formula: C28H30F2N2O2
(3E,5E)-1-[(2,5-Dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-4-piperidinone - Names and Identifiers
(3E,5E)-1-[(2,5-Dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-4-piperidinone - Physico-chemical Properties
| Molecular Formula | C28H30F2N2O2 |
| Molar Mass | 464.55 |
| Solubility | DMSO: ≥ 32 mg/mL |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Use | HO-3867 is an effective and selective STAT3 inhibitor with good anti-tumor activity. |
| In vitro study | HO-3867 produced significant cytotoxicity in A2780 and other ovarian cancer cell lines tested, with lower toxicity to non-cancerous ovarian epithelial cells. HO-3867 induces G(2)-M cell cycle arrest in A2780 cells and promotes apoptosis through caspase-8 and caspase-3 activation. HO-3867 blocks the JAK/STAT3 pathway in human ovarian cancer cell lines. |
| In vivo study | HO-3867 (100 ppm, P. O.) inhibits the growth of ovarian cancer xenografts in mice without a significant toxic signal, inhibits pSTAT3, and down-regulates STAT3 targeting proteins. HO-3867 sensitizes cisplatin-resistant ovarian cancer by inhibition of STAT3. HO-3867 (100 ppm p. O.) attenuates left ventricular failure-induced pulmonary hypertension by reducing oxidative stress and increasing PTEN expression in rat lungs. |
(3E,5E)-1-[(2,5-Dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-4-piperidinone - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.153 ml | 10.763 ml | 21.526 ml |
| 5 mM | 0.431 ml | 2.153 ml | 4.305 ml |
| 10 mM | 0.215 ml | 1.076 ml | 2.153 ml |
| 5 mM | 0.043 ml | 0.215 ml | 0.431 ml |
Last Update：2024-01-02 23:10:35
![(3E,5E)-1-[(2,5-Dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-4-piperidinone](http://res.chembk.com/assets/str/2d/1/11/1172133-28-6.png)
Supplier List
Spot supply
Product Name: HO-3867 Visit Supplier Webpage Request for quotationCAS: 1172133-28-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: HO-3867 Visit Supplier Webpage Request for quotationCAS: 1172133-28-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History